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DHEA-sulfate blood test measures the amount of DHEA-sulfate in the blood.

Blood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The puncture site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.

Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.

In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.

No special preparation is necessary. However, tell your health care provider if you are taking any vitamins or supplements that contain DHEA or DHEA-sulfate.

When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or sting. Afterward, there may be some throbbing.

This test is used to evaluate the function of the adrenal glands. DHEA-sulfate is a weak male hormone (androgen) produced by the adrenal gland in both men and women. The adrenal gland is one of the major sources of androgens in women (the other being the ovaries, which produce testosterone).

DHEA-sulfate is measured in women showing symptoms of male body characteristics (virilism) or excessive hair growth (hirsutism). It is also done in children who are maturing too early (precocious puberty).

Normal values for serum DHEA sulfate can differ by sex and age.

Typical normal ranges for females are:

• Age 18-19: 145-395 ug/dL
• Age 20-29: 65-380 ug/dL
• Age 30-39: 45-270 ug/dL
• Age 40-49: 32-240 ug/dL
• Age 50-59: 26-200 ug/dL
• Age 60-69: 13-130 ug/dL
• Age 69 and older: 17-90 ug/dL

Typical normal ranges for males are:

• Age 18-19: 108-441 ug/dL
• Age 20-29: 280-640 ug/dL
• Age 30-39: 120-520 ug/dL
• Age 40-49: 95-530 ug/dL
• Age 50-59: 70-310 ug/dL
• Age 60-69: 42-290 ug/dL
• Age 69 and older: 28-175 ug/dL

Note: ug/dL = microgram per deciliter

Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

An increase in DHEA-sulfate may indicate:

• Adrenal carcinoma
• Congenital adrenal hyperplasia
• Polycystic ovary syndrome
• Tumor of the adrenal gland

Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight but may include:

• Excessive bleeding
• Fainting or feeling light-headed
• Hematoma (blood accumulating under the skin)
• Infection (a slight risk any time the skin is broken)

Serum DHEA-sulfate; dehydroepiandrosterone-sulfate

Guber HA, Farag AF, Lo J, Sharp J. Evaluation of Endocrine Function. In: McPherson RA, Pincus MR. McPherson & Pincus: Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. Philadelphia, Pa:W. B. Saunders Company;2006:chap 24.

Updated by: Elizabeth H. Holt, MD, PhD, Assistant Professor of Medicine, Section of Endocrinology and Metabolism, Yale University. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.